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p gp  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc p gp
    P Gp, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 110 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/p+gp/Rheb+Rabbit+mAb/pmc13031540-59-11-20
    Average 95 stars, based on 110 article reviews
    p gp - by Bioz Stars, 2026-10
    95/100 stars

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    Related Articles

    Staining:

    Article Title: Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
    Article Snippet: .. Decalcified tissues were paraffin embedded and cut into 4 μm coronal sections that were stained with hematoxylin and eosin (H&E), and for human Vimentin (1:4,000; M0725; DakoCytomation; Glostrup, Denmark), P-gp (1:200; 13978; Cell Signaling Technology; Danvers, MA), BCRP (1:400; ab24115; Abcam; Cambridge, UK), mouse IgG (K4001, Dako) and MELpT-KNL1 (1:50; as described previously [ , ]). .. Sections were imaged and processed using an Aperio AT2 system and ImageScope software (v12; both Leica).

    Article Title: Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma.
    Article Snippet: .. Decalcified tissues were paraffin embedded and cut into 4 μm coronal sections that were stained with hematoxylin and eosin (H&E), and for human Vimentin (1:4,000; M0725; DakoCytomation; Glostrup, Denmark), P-gp (1:200; 13978; Cell Signaling Technology; Danvers, MA), BCRP (1:400; ab24115; Abcam; Cambridge, UK), mouse IgG (K4001, Dako) and MELpT-KNL1 (1:50; as described previously [30, 31]). .. Sections were imaged and processed using an Aperio AT2 system and ImageScope software (v12; both Leica).

    Cell-Signaling:

    Article Title: Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
    Article Snippet: .. Decalcified tissues were paraffin embedded and cut into 4 μm coronal sections that were stained with hematoxylin and eosin (H&E), and for human Vimentin (1:4,000; M0725; DakoCytomation; Glostrup, Denmark), P-gp (1:200; 13978; Cell Signaling Technology; Danvers, MA), BCRP (1:400; ab24115; Abcam; Cambridge, UK), mouse IgG (K4001, Dako) and MELpT-KNL1 (1:50; as described previously [ , ]). .. Sections were imaged and processed using an Aperio AT2 system and ImageScope software (v12; both Leica).

    Article Title: Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma.
    Article Snippet: .. Decalcified tissues were paraffin embedded and cut into 4 μm coronal sections that were stained with hematoxylin and eosin (H&E), and for human Vimentin (1:4,000; M0725; DakoCytomation; Glostrup, Denmark), P-gp (1:200; 13978; Cell Signaling Technology; Danvers, MA), BCRP (1:400; ab24115; Abcam; Cambridge, UK), mouse IgG (K4001, Dako) and MELpT-KNL1 (1:50; as described previously [30, 31]). .. Sections were imaged and processed using an Aperio AT2 system and ImageScope software (v12; both Leica).



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    Image Search Results


    HSP70 enhances P-gp protein stability by regulating SUMOylation of P-gp. (A, B) P-gp expression evaluated by RT-qPCR and western blot; (C) SUMOylation sites of P-gp predicted using the online GPS-SUMO database; (D) Interaction between P-gp and HSP70 and SUMOylation levels of P-gp assessed by Co-IP assay; (E) The SUMOylation levels of wild-type and mutant P-gp measured with Co-IP assay; (F) P-gp protein stability evaluated by CHX chase assay. All cell experiments were independently repeated three times. Data were presented as mean ± SD. Comparisons among multiple groups were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test. ** P < 0.01, *** P < 0.001.

    Journal: Frontiers in Immunology

    Article Title: HSP70-mediated regulation of P-glycoprotein SUMOylation suppresses ferroptosis to drive thermoresistance in non-small cell lung cancer

    doi: 10.3389/fimmu.2026.1844793

    Figure Lengend Snippet: HSP70 enhances P-gp protein stability by regulating SUMOylation of P-gp. (A, B) P-gp expression evaluated by RT-qPCR and western blot; (C) SUMOylation sites of P-gp predicted using the online GPS-SUMO database; (D) Interaction between P-gp and HSP70 and SUMOylation levels of P-gp assessed by Co-IP assay; (E) The SUMOylation levels of wild-type and mutant P-gp measured with Co-IP assay; (F) P-gp protein stability evaluated by CHX chase assay. All cell experiments were independently repeated three times. Data were presented as mean ± SD. Comparisons among multiple groups were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test. ** P < 0.01, *** P < 0.001.

    Article Snippet: Beginning in the second week after hyperthermia initiation, mice received tail vein injections of the P-gp inhibitor verapamil (25 mg/kg; HY-14275, MCE) thrice per week for three weeks , wherein verapamil was dissolved sequentially in 10% DMSO, 40% polyethylene glycol 300, 5% Tween-80, and 45% saline.

    Techniques: Expressing, Quantitative RT-PCR, Western Blot, Co-Immunoprecipitation Assay, Mutagenesis

    Knockdown of P-gp facilitates ferroptosis, which partially reverses the promoting effect of HSP70 on the resistance of NSCLC cells to hyperthermia. (A, B) RT-qPCR and western blot to evaluate P-gp expression in cells; (C) LDH to assess cell death; (D) BODIPY staining to examine lipid peroxidation; (E–G) Test kit to detect Fe 2+ , MDA, and GSH levels in cells; (H) Western blot to assess ferroptosis-related proteins (GPX4 and SLC7A11) in cells; (I) CCK-8 to examine cell viability; (J) Transwell to assess cell invasion and migration. Cell experiments were repeated thrice. Data were exhibited as mean ± SD. One-way ANOVA was utilized for data comparisons among multiple groups, and Tukey’s multiple comparison test was employed for the post hoc test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Journal: Frontiers in Immunology

    Article Title: HSP70-mediated regulation of P-glycoprotein SUMOylation suppresses ferroptosis to drive thermoresistance in non-small cell lung cancer

    doi: 10.3389/fimmu.2026.1844793

    Figure Lengend Snippet: Knockdown of P-gp facilitates ferroptosis, which partially reverses the promoting effect of HSP70 on the resistance of NSCLC cells to hyperthermia. (A, B) RT-qPCR and western blot to evaluate P-gp expression in cells; (C) LDH to assess cell death; (D) BODIPY staining to examine lipid peroxidation; (E–G) Test kit to detect Fe 2+ , MDA, and GSH levels in cells; (H) Western blot to assess ferroptosis-related proteins (GPX4 and SLC7A11) in cells; (I) CCK-8 to examine cell viability; (J) Transwell to assess cell invasion and migration. Cell experiments were repeated thrice. Data were exhibited as mean ± SD. One-way ANOVA was utilized for data comparisons among multiple groups, and Tukey’s multiple comparison test was employed for the post hoc test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Article Snippet: Beginning in the second week after hyperthermia initiation, mice received tail vein injections of the P-gp inhibitor verapamil (25 mg/kg; HY-14275, MCE) thrice per week for three weeks , wherein verapamil was dissolved sequentially in 10% DMSO, 40% polyethylene glycol 300, 5% Tween-80, and 45% saline.

    Techniques: Knockdown, Quantitative RT-PCR, Western Blot, Expressing, Staining, CCK-8 Assay, Migration, Comparison

    HSP70 suppresses oxidative stress and mitochondrial dysfunction by upregulating P-gp. (A, B) Measurement of intracellular ROS and SOD levels using commercial kits; (C) Assessment of MMP assessed by JC-1 fluorescent probe; (D) Measurement of mtDNA levels; (E–H) Real-time monitoring curves of OCR in cells, along with quantitative analyses of basal respiration, ATP synthesis, and maximal respiration levels. All cell experiments were independently repeated three times. Data were presented as mean ± SD. Comparisons among groups were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Journal: Frontiers in Immunology

    Article Title: HSP70-mediated regulation of P-glycoprotein SUMOylation suppresses ferroptosis to drive thermoresistance in non-small cell lung cancer

    doi: 10.3389/fimmu.2026.1844793

    Figure Lengend Snippet: HSP70 suppresses oxidative stress and mitochondrial dysfunction by upregulating P-gp. (A, B) Measurement of intracellular ROS and SOD levels using commercial kits; (C) Assessment of MMP assessed by JC-1 fluorescent probe; (D) Measurement of mtDNA levels; (E–H) Real-time monitoring curves of OCR in cells, along with quantitative analyses of basal respiration, ATP synthesis, and maximal respiration levels. All cell experiments were independently repeated three times. Data were presented as mean ± SD. Comparisons among groups were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Article Snippet: Beginning in the second week after hyperthermia initiation, mice received tail vein injections of the P-gp inhibitor verapamil (25 mg/kg; HY-14275, MCE) thrice per week for three weeks , wherein verapamil was dissolved sequentially in 10% DMSO, 40% polyethylene glycol 300, 5% Tween-80, and 45% saline.

    Techniques:

    HSP70-mediated SUMOylation regulates P-gp to inhibit ferroptosis and thus boost resistance to hyperthermia and tumor growth in vivo . (A) Tumor images and weights; (B) Lipid peroxidation assessed by BODIPY staining; (C–F) Intratumoral ROS, Fe 2+ , MDA, and GSH levels; (G, H) Expression of ferroptosis-related proteins (GPX4 and SLC7A11), SUMO1, and SUMO2/3 detected by western blot; (I) HSP70 level in tumor tissues measured by RT-qPCR. n = 6. Data were presented as mean ± SD. Comparisons among groups were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Journal: Frontiers in Immunology

    Article Title: HSP70-mediated regulation of P-glycoprotein SUMOylation suppresses ferroptosis to drive thermoresistance in non-small cell lung cancer

    doi: 10.3389/fimmu.2026.1844793

    Figure Lengend Snippet: HSP70-mediated SUMOylation regulates P-gp to inhibit ferroptosis and thus boost resistance to hyperthermia and tumor growth in vivo . (A) Tumor images and weights; (B) Lipid peroxidation assessed by BODIPY staining; (C–F) Intratumoral ROS, Fe 2+ , MDA, and GSH levels; (G, H) Expression of ferroptosis-related proteins (GPX4 and SLC7A11), SUMO1, and SUMO2/3 detected by western blot; (I) HSP70 level in tumor tissues measured by RT-qPCR. n = 6. Data were presented as mean ± SD. Comparisons among groups were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Article Snippet: Beginning in the second week after hyperthermia initiation, mice received tail vein injections of the P-gp inhibitor verapamil (25 mg/kg; HY-14275, MCE) thrice per week for three weeks , wherein verapamil was dissolved sequentially in 10% DMSO, 40% polyethylene glycol 300, 5% Tween-80, and 45% saline.

    Techniques: In Vivo, Staining, Expressing, Western Blot, Quantitative RT-PCR

    HSP70-mediated SUMOylation modulates P-gp in vivo . (A, B) IHC analysis of HSP70-positive cells and P-gp-positive cells in nude mouse tumor tissues. n = 6. Data were presented as mean ± SD. Comparisons among groups were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Journal: Frontiers in Immunology

    Article Title: HSP70-mediated regulation of P-glycoprotein SUMOylation suppresses ferroptosis to drive thermoresistance in non-small cell lung cancer

    doi: 10.3389/fimmu.2026.1844793

    Figure Lengend Snippet: HSP70-mediated SUMOylation modulates P-gp in vivo . (A, B) IHC analysis of HSP70-positive cells and P-gp-positive cells in nude mouse tumor tissues. n = 6. Data were presented as mean ± SD. Comparisons among groups were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Article Snippet: Beginning in the second week after hyperthermia initiation, mice received tail vein injections of the P-gp inhibitor verapamil (25 mg/kg; HY-14275, MCE) thrice per week for three weeks , wherein verapamil was dissolved sequentially in 10% DMSO, 40% polyethylene glycol 300, 5% Tween-80, and 45% saline.

    Techniques: In Vivo